Medical breakthroughs that were initially ridiculed or rejected

[1] Although medical science most often advances

incrementally on the basis of an ever-accumulating body of 

evidence, occasionally leaps forward are made. Quite often 

[4] these leaps fly in the face of conventional wisdom, and are 

ridiculed or rejected by the medical establishment.

Ignaz Semmelweis was a Hungarian physician 

[7] working in a maternity ward in Vienna in the mid-19th century. 

He came to the conclusion that puerperal fever was contagious 

by observing that students and physicians were performing 

[10] autopsies and then attending new mothers, many of whom 

would soon become ill and die. 

He then advocated that doctors in obstetric clinics 

[13] disinfect their hands following autopsies. The result: at the 

clinic in which his hand-washing policy was implemented, the 

puerperal fever mortality rates dropped from 18.3% to less than 

[16] 2% in fewer than 6 months. 

Despite Semmelweis’s demonstration of the value of 

antiseptic techniques, by and large his ideas were rejected by 

[19] the medical community. Because of this, he began publishing 

a series of vitriolic “open letters” against his critics. Isolated 

and unpredictable, Semmelweis was admitted against his will 

[22] to an insane asylum, where he died after two weeks. 

Gabriel Miller. Internet: (adapted). 

Based on the text, judge the following item. 

In line 4, “fly in the face of conventional wisdom” can be correctly replaced by go against accepted knowledge without this changing the meaning of the text.